Mechanical behavior of optimized optical nanomultilayers

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How and when do big data investments pay off? The role of marketing affordances and service innovation

Big data technologies and analytics enable new digital services and are often associated with superior performance. However, firms investing in big data often fail to attain those advantages. To answer the questions of how and when big data pay off, marketing scholars need new theoretical approaches and empirical tools that account for the digitized world. Building on affordance theory, the authors develop a novel, conceptually rigorous, and practice-oriented framework of the impact of big data investments on service innovation and performance. Affordances represent action possibilities, namely what individuals or organizations with certain goals and capabilities can do with a technology. The authors conceptualize and operationalize three important big data marketing affordances: customer behavior pattern spotting, real-time market responsiveness, and data-driven market ambidexterity. The empirical analysis establishes construct validity and offers a preliminary nomological test of direct, indirect, and conditional effects of big data marketing affordances on perceived big data performance

Effect on albumin and fibronectin adsorption of silver doping via ionic exchange of a silica-based bioactive glass

Protein adsorption is a crucial step in the life of biomaterials for bone application, such as bioactive glasses. The investigation of adsorption mechanisms is a difficult task per se, which is even more complex on bioactive glasses due to surface reactivity. Here, the effect of silver doping by ionic exchange on the interaction of a silica-based bioactive glass with albumin and fibronectin, serum proteins related to osseointegration, is reported. The presence of silver does not change relevant surface properties such as topography, surface energy, wettability, or surface ζ potential. Nevertheless, the interactions with proteins are much different. The presence of silver significantly increases the adsorption of albumin and fibronectin and leads to a higher loss of secondary structure compared to the undoped surface, as a consequence of the interactions and bonding between silver and thiols in the cysteine residues. Selectivity of silver-doped glass is discovered: Ag enhances more adsorption and dena- turation of albumin since it has more cysteines than fibronectin. It is also here observed that due to the formation of a hydrated silica gel layer during adsorption, proteins are not only present on the surface of the bioactive glasses, but also embedded inside the surface reaction laye

A strong-coupling analysis of two-dimensional O(N) sigma models with N≥3N\geq 3 on square, triangular and honeycomb lattices

Recently-generated long strong-coupling series for the two-point Green's functions of asymptotically free ${\rm O}(N)$ lattice $\sigma$ models are analyzed, focusing on the evaluation of dimensionless renormalization-group invariant ratios of physical quantities and applying resummation techniques to series in the inverse temperature $\beta$ and in the energy $E$. Square, triangular, and honeycomb lattices are considered, as a test of universality and in order to estimate systematic errors. Large-$N$ solutions are carefully studied in order to establish benchmarks for series coefficients and resummations. Scaling and universality are verified. All invariant ratios related to the large-distance properties of the two-point functions vary monotonically with $N$, departing from their large-$N$ values only by a few per mille even down to $N=3$.Comment: 53 pages (incl. 5 figures), tar/gzip/uuencode, REVTEX + psfi

Quadrupole scan emittance measurements for the ELI-NP compton gamma source

The high brightness electron LINAC of the Compton Gamma Source at the ELI Nuclear Physics facility in Roma- nia is accelerating a train of 32 bunches with a nominal total charge of 250 pC and nominal spacing of 16 ns . To achieve the design gamma flux, all the bunches along the train must have the designed Twiss parameters. Beam sizes are mea- sured with optical transition radiation monitors, allowing a quadrupole scan for Twiss parameters measurements. Since focusing the whole bunch train on the screen may lead to permanent screen damage, we investigate non-conventional scans such as scans around a maximum of the beam size or scans with a controlled minimum spot size. This paper discusses the implementation issues of such a technique in the actual machine layou

Local treatment with electrochemotherapy of superficial angiosarcomas: Efficacy and safety results from a multi-institutional retrospective study

Background: Angiosarcoma is an aggressive vascular neoplasm with a high propensity for local recurrence. Electrochemotherapy is an emerging skin-directed therapy, exerting prominent cytotoxic activity, and antivascular effects. Its efficacy in angiosarcoma has not been investigated. Methods: This multicenter retrospective analysis reviewed patients who underwent electrochemotherapy from 2007 to 2014 for superficial advanced angiosarcomas. Bleomycin was administered intravenously and delivered within tumors by means of percutaneously applied electric pulses, according to the European Standard Operating Procedures for Electrochemotherapy. Tumor assessment was performed using RECIST (version 1.1). Toxicity (CTCAE, v4.0) and local progression-free survival (LPFS) were also evaluated. Results: Nineteen patients (13 with locally advanced and 6 with metastatic angiosarcomas) were treated. Tumor sites were: scalp (n¼5), breast(n¼8), other skin sites (n¼3), and soft tissue (n¼3). Target lesions (n¼54) ranged in size from 1.5 to 2.5 cm (median, 2 cm). Treatment was well tolerated. After 2 months, an objective response was observed in 12/19 (63%) patients, complete in 8 (42%). One-year LPFS within treatment field was 68%. Local symptom improvement included palliation of bleeding (5/19 patients) and pain relief (6/19 patients). Conclusions: Electrochemotherapy may represent a new locoregional treatment for selected patients with superficial angiosarcomas

Endovascular management of giant visceral artery aneurysms

Endovascular management of small visceral artery aneurysms is an established treatment with satisfactory outcomes. However, when size exceeds 5 cm visceral aneurysms are considered as “giant” (giant visceral artery aneurysms or GVAAs) and management is significantly more complex. Between August 2007 and June 2019 eleven cases of GVAAs that were endovascularly treated were retrospectively reviewed and included in this single center study. Mean size was 80 mm (± 26.3 mm) x 46 mm (+ -11.8 mm). Nine of the lesions were true aneurysms, and two were pseudoaneurysms. In 8 patients, the lesion was causing compression symptoms in the surrounding organs, one patient developed a contained rupture while 2 patients were completely asymptomatic. However, all patients were hemodynamically stable at the time of treatment. Technical success was defined as immediate complete exclusion of the aneurysmal sac, and clinical success as complete relief from clinical symptoms. Follow-up was performed with CT angiography, ultrasound and clinical examination. Mean follow-up was 45 months (range 6–84). Technical and clinical success were both 91%. Complications were one lack of control of contained rupture that was subsequently operated, one case of self-limiting non-target spleen embolization and one case of splenic abscess. Three patients died, one due to the contained rupture 15 days after procedure, the other two for other causes and occurred during the long-term follow-up. This series suggests that endovascular treatment of giant visceral artery aneurysms and pseudoaneuryms is a valid minimally invasive solution with very satisfactory immediate and long-term outcomes unless the aneurysm is already ruptured. A variety of endovascular tools may be required for successful treatment

Efficient plasma wakefield acceleration simulations via kinetic-hydro code

Start-to-end simulations are needed for sensitivity stud- ies and online analysis of experimental data of the Plasma Wakefield Acceleration experiment COMB at SPARC_LAB facility, Frascati (Italy). Ad hoc tools are needed for the plasma section modeling. Particle in cell codes are the most widely used tools for this purpose, but they suffer from the considerable amount of computational resources they re- quire. We seek for a simple, portable, quick-to-run approach. For this purpose we introduce a time-explicit cylindrical hybrid fluid-kinetic code: Architect. The beam particles are treated with PIC-like kinetic approach, while the plasma wake is treated as a fluid. Since the number of computational particles used by the hybrid model is significantly reduced with respect of full PIC codes with the same number of di- mensions, the time required for a simulation is reduced as well